Ohrym S. A.
Pages: 25-27.

Full article: 

---

Abstract

The purpose. To study effect of antibiotic of prolonged action Oksiprol on processes of peroxide oxidation of lipids and activity of ferments of antioxidant systems of blood of cows during dry period. Methods. Biochemical, photometric, statistical. To cows of experimental group 30 day prior to calving intramuscularly inducted a specimen Oksiprol in dose of 1 cm3 for 10 kg of mass of a body. Results. After application of Oksiprol during dry period the content of diene conjugates in blood serum drops for 28,47% (P<=0,01), of malonic dial — for 12,5% (P<=0,05), while catalase activity increases for 36,47% (P<=0,01), and density of hepatocuprein — for 30,55% (P<=0,01) in comparison with the beginning of experiment, on the background of uncertain fluctuation of the content of these indexes in blood of cows of control group. Conclusions. Application of Oksiprol in dry period makes active enzymatic link of antioxidant protection of an organism, slows down activity of processes of peroxide oxidation of lipids, which prevent development of morbid conditions. With the purpose of prophylactics of development of morbid conditions at cows it is recommended

---

Key words: cows, dry period, antibiotics, lipid peroxidation, antioxidant system of blood

---

References

1. Yablonsky, V.A., & Lyubetsky, V.J., & Yukhymchuk, S.K., & et al. (2000). Vidtvoryuval'na zdatnist' koriv v umovakh kryzovoho stanu hospodarstva [The reproductive ability of cows in conditions of crisis state farming]. Naukovyy visnyk Natsional'noho ahrarnoho universytetu. Problemy fiziolohiyi i patolohiyi vidtvorennya tvaryn – Scientific Bulletin of National Agrarian University. Problems of physiology and pathology of animal reproduction 22. Kyiv, 75-77 [in Ukrainian].
2. Bradley, A. J., & Breen, J.E., & Payne B., & Green, M.J. (2011). A comparison of broad-spectrum and narrow-spectrum dry cow therapy used alone and in combination with a teat sealant. Journal of Dairy Science, Vol. 94, Issue 2, 692-704 [in English].
3. Collier, R.J., & Annen-Dawson, E.L., & Pezeshki, A. (2012). Effects of continuous lactation and short dry periods on mammary function and animal health. Animal, Mar;6(3):403-14 [in English].
4. Cameron, M., & McKenna, S.L., & MacDonald, K.A., & Dohoo, I.R., & Roy, J.P., & Keefe, G.P. (2014). Evaluation of selective dry cow treatment following on-farm culture: risk of postcalving intramammary infection and clinical mastitis in the subsequent lactation. Journal of Dairy Science, Jan;97(1):270-84 [in English].
5. Cameron, M., & Keefe, G.P., & Roy, J.P., & Stryhn, H., & Dohoo, I.R., & McKenna, S.L. (2015). Evaluation of selective dry cow treatment following on-farm culture: Milk yield and somatic cell count in the subsequent lactation. Journal of Dairy Science, Apr;98(4):2427-36 [in English].
6. Cameron, M., & Keefe, G.P., & Roy, J.P., & Dohoo, I.R., & MacDonald, K.A, & McKenna, S.L. (2013). Evaluation of a 3M Petrifilm on-farm culture system for the detection of intramammary infection at the end of lactation. Prev. Vet. Med., Aug 1;111(1-2):1-9 [in English].
7. Klenowa, I.F., & Maltsev, K.JI., & Yaremenko, N.Y., & Arkhipov, I.A. (2004). Veterynarnble preparatbl v Rossyy: spravochnyk v 2-kh tomakh [Veterinary preparations in Russia: a handbook in 2 volumes]. Moscow: Selhozizdat, Part 1[in Russian].
8. Grechuhin, A.N. (2006). Novoe sredstvo pry bakteryal'nom symptomokomplekse [A new remedy for bacterial symptom complex]. Veterynaryya – Veterinary medicine;8,6-8 [in Russian].
9. Bradley, A.J., & Breen, J.E., & Payne, B., & Williams, P., & Green, M.J. (2010). The use of a cephalonium containing dry cow therapy and an internal teat sealant, both alone and in combination. Journal of Dairy Science;93:1566-1577 [in English].
10. Bradley, A.J., & Green, M.J. (2001). An investigation of the impact of intramammary antibiotic dry cow therapy on clinical coliform mastitis. Journal of Dairy Science;84:1632-1639 [in English].
11. Bachman, K.C., & Schairer M.L. (2003). Invited review: bovine studies on optimal lengths of dry periods. Journal of Dairy Science, Vol. 86, No. 10:3027-3037 [in English].
12. Pezeshki, A., & Capuco, A.V., & De Spiegeleer B., & Peelman L., & Stevens M., & Collier R.J., & Burvenich C. (2010). An integrated view on how the management of the dry period length of lactating cows could affect mammary biology and defence. J. Anim. Physiol. Anim. Nutr. (Berl), Oct;94(5):e7-30 [in English].
13. Scherpenzeel, C.G., & den Uijl, I.E., & van Schaik, G., & Olde Riekerink, R.G., & Keurentjes, J.M., & Lam, T.J. (2014). Evaluation of the use of dry cow antibiotics in low somatic cell count cows. Journal of Dairy Science, Jun;97(6):3606-14 [in English].
14. Petzer I.M., & Lourens D.C., & Watermeyer J.C., & Rautenbach G.H., & Thompson P. (2009). Intramammary infection rate during the dry period in cows that received blanket dry cow therapy: efficacy of 6 different dry-cow intra-mammary antimicrobial products. J. South. African. Vet. Assoc.;1: 23-30 [in English].
15. Vladimirov, Yu.A., & Archakov, A.I. (1972). Perekysnoe okyslenye lypydov v byolohycheskykh membranakh [Lipid peroxidation in biological membranes]. Moscow: Nauka [in Russian].
16. Lankin, V.Z., & Tihaze, A.K., & Belenkov, Y.M. (2001). Svobodnoradykalnble protsessbl v norme y pry patolohycheskykh sostoianyiakh: Posobye dlia vrachei [Free-radical processes in normal and pathological conditions: A Handbook for Physicians]. Moscow: Science [in Russian].
17. Shcherban, N.G., & Gorbach, T.V., & Guseva N.R. (2004). Laboratornble metodyky dlya yzuchenyya sostoyanyya antyoksydantnoy systembl orhanyzma y urovnya perekysnoho okyslenyya lypydov: Metodycheskye rekomendatsyy dlya doktorantov, aspyrantov, mahystrov, yspolnyteley NYR. [Laboratory techniques for the study of the state of antioxidant system and lipid peroxidation: Guidelines for doctoral students, graduate students, masters, artists research]. Kharkov: HGMU [in Russian].
18. Lakyn, G.F. (1990). Byometryya: Uchebnoe posobye dlya byolohycheskykh spetsyal'nostey vuzov. [Biometrics: A manual for biological specialties universities] Moscow: Higher School [in Russian].